SB features

S. boulardii features

Documented probiotic yeast for gut health benefits

S. boulardii has been discovered in 1923 by Henri Boulard during a cholera epidemic in Vietnam on tropical fruits skin and was first marketed in 1953 as a drug to prevent acute diarrhea.

Since then, the yeast S. boulardii has been documented in several acute and chronic gut disorders: preventive treatment of antibiotic-associated diarrhea, Helicobacter pylori and Clostridium difficile infections or traveler’s diarrhea [Hojsak, 2018]. It has shown to reduce the duration of occasional diarrhea by approximately one day.

  • Analysed in over 100 clinical studies.
  • Proven reliable and harmless for children and adults.
  • Recommended by the European Society for Paediatric Gastroenterology Hepathology and Nutrition (ESPGHAN).

Mechanisms of action


Luminal effect

  • Provides antimicrobial action by binding to opportunistic bacteria.
  • Produces a neutralizing effect by secreting proteins that inactivate metabolites of opportunistic bacteria. 


Trophic action

  • Ensures barrier integrity by strengthening the tight junctions of epithelial cells.
  • Improves intestinal mucosa metabolism: SCFAs production, enzymes enhancement, antioxidant activity.


Immunity modulation

  • Stimulates the immune system, both innate and adaptative immunity. 
  • Modulates the imminue signalling pathways.



Scientific evidences

1. In vitro mechanistic evidence on S. boulardii CNCM I-1079

[Gaisawat, 2019] – Antioxidant activity and intestinal metabolic homeostasis restoration in C. difficile model

  • S. boulardii restored altered redox status associated with C. difficile infection by significantly increasing copper chelation (p<0.05) thereby reducing metal’s bioavailability used to catalyze free radical polymerization. 
  • S. boulardii significantly increased total SCFAs production (e.g. acetate, butyrate)
  • S. boulardii restored H2S level

[Audy, 2012] – Pro-inflammatory response down-regulation

  • S. boulardii reduced gene expression involved in pro-inflammatory cytokine production.


2. In vivo scientific evidence on S. boulardii CNCM I-1079

[West, 2016] – Acute stress-related intestinal dysmotility model

  • S. boulardii reversed the effects of stress on small and large intestines, returning them to unstressed levels: velocity restoration (p<0.001) and frequency regulation (p<0.005). 



  • 51% of consumers turn to probiotic products for digestive health purpose (1).
  • 75% of probiotic supplements are sold worldwide to support digestive discomfort – 5% of these contain the probiotic yeast S. boulardii (2).

References: (1) – FMCG GURU (2) – Lumina Product 2020